Nancy Ratner Selected Research

Peripheral Nervous System Neoplasms

1/2013	MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.
5/2006	Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma.

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Nancy Ratner Research Topics

Disease

49	Neoplasms (Cancer) 01/2022 - 02/2002
28	Neurofibroma 01/2022 - 12/2003
27	Neurofibrosarcoma (MPNST) 01/2022 - 01/2005
19	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/2021 - 01/2004
12	Neurofibromatoses (Neurofibromatosis) 01/2021 - 11/2002
8	Sarcoma (Soft Tissue Sarcoma) 01/2022 - 10/2012
8	Plexiform Neurofibroma 01/2021 - 02/2012
7	Carcinogenesis 01/2019 - 03/2003
6	Neurilemmoma (Schwannoma) 01/2020 - 02/2002
4	Glioblastoma (Glioblastoma Multiforme) 11/2018 - 01/2018
4	Schwannomatosis 01/2018 - 03/2012
3	Glioma (Gliomas) 01/2021 - 03/2012
3	Fibrosis (Cirrhosis) 07/2020 - 05/2006
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2020 - 12/2004
3	Neurofibromatosis 2 (Neurofibromatosis Type II) 01/2019 - 02/2002
3	Nerve Sheath Neoplasms (Nerve Sheath Neoplasm) 09/2014 - 01/2012
2	Pain (Aches) 01/2021 - 01/2021
2	Meningioma (Meningiomas) 01/2019 - 03/2012
2	Ependymoma 01/2019 - 03/2012
2	Neuroblastoma 03/2017 - 01/2009
2	Peripheral Nervous System Neoplasms 01/2013 - 05/2006
1	Necrosis 01/2019
1	Melanoma (Melanoma, Malignant) 10/2018
1	Renal Cell Carcinoma (Grawitz Tumor) 10/2018
1	Ovarian Neoplasms (Ovarian Cancer) 03/2018
1	Adenocarcinoma of Lung 03/2018
1	Legius syndrome 01/2018
1	Musculoskeletal Abnormalities 01/2018
1	Exanthema (Rash) 12/2016
1	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 04/2016
1	Hepatocellular Carcinoma (Hepatoma) 04/2016

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2002
10	ErbB Receptors (EGF Receptor)IBA 07/2014 - 03/2003
9	Neurofibromin 1 (Neurofibromin)IBA 01/2020 - 01/2004
8	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022 - 01/2013
6	CateninsIBA 03/2021 - 03/2013
6	Small Interfering RNA (siRNA)IBA 01/2021 - 03/2006
6	Guanosine Triphosphate (GTP)IBA 07/2020 - 11/2002
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021 - 11/2008
4	CytokinesIBA 07/2020 - 02/2016
4	Neurofibromin 2 (Merlin)IBA 01/2019 - 02/2002
4	Biomarkers (Surrogate Marker)IBA 04/2016 - 03/2006
3	AZD 6244IBA 01/2021 - 12/2016
3	LigandsIBA 01/2021 - 10/2012
3	mirdametinibIBA 01/2021 - 01/2013
3	Aurora Kinase AIBA 01/2020 - 09/2012
3	Mitogen-Activated Protein KinasesIBA 01/2020 - 01/2015
3	Adenylate KinaseIBA 11/2018 - 01/2018
3	Pharmaceutical PreparationsIBA 10/2015 - 02/2012
3	Everolimus FDA Link 03/2014 - 05/2008
3	CollagenIBA 08/2007 - 01/2005
2	Cyclin-Dependent Kinase Inhibitor p16IBA 11/2020 - 03/2006
2	Aurora KinasesIBA 01/2020 - 09/2012
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2019 - 05/2006
2	Protein Isoforms (Isoforms)IBA 01/2018 - 02/2002
2	MLN 8237IBA 03/2017 - 09/2012
2	Conditioned Culture MediaIBA 01/2017 - 10/2010
2	LipidsIBA 12/2015 - 04/2004
2	ras GTPase-Activating Proteins (ras-GAP)IBA 10/2015 - 01/2006
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 07/2012 - 01/2012
2	TensinsIBA 07/2012 - 01/2012
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 05/2008 - 02/2007
2	OligonucleotidesIBA 03/2006 - 12/2004
2	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 01/2006 - 01/2004
1	Angiogenesis InhibitorsIBA 01/2022
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2022
1	Purinergic Receptors (Receptors, Purine)IBA 01/2021
1	ArrestinIBA 01/2021
1	Peptide Nucleic AcidsIBA 01/2021
1	Purinergic AgonistsIBA 01/2021
1	diphosphoric acid (pyrophosphoric acid)IBA 11/2020
1	Protein Kinases (Protein Kinase)IBA 01/2020
1	Cytostatic AgentsIBA 01/2020
1	Polo-Like Kinase 1IBA 01/2020
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2020
1	CXCR3 ReceptorsIBA 02/2019
1	Chemokine CXCL10IBA 02/2019
1	Dual-Specificity PhosphatasesIBA 01/2019
1	Myelin ProteinsIBA 01/2019
1	FLLL 32IBA 01/2019
1	2- benzylidene- 3- (cyclohexylamino)- 2,3- dihydro- 1H- inden- 1- oneIBA 01/2019
1	Core Binding Factors (Core-Binding Factor)IBA 01/2019
1	Adenosine Triphosphate (ATP)IBA 11/2018
1	Messenger RNA (mRNA)IBA 10/2018
1	Superoxides (Superoxide)IBA 03/2018
1	Uvitex SWN (SWN)IBA 01/2018
1	HLA-A Antigens (HLA-A)IBA 10/2017
1	Interferon Type IIBA 01/2017
1	Polyethylene (Polythene)IBA 01/2017
1	Creatine Kinase (Creatine Phosphokinase)IBA 12/2016
1	silmitasertibIBA 08/2016
1	RNA (Ribonucleic Acid)IBA 07/2016
1	Transcription Factors (Transcription Factor)IBA 07/2016
1	Histone Deacetylase InhibitorsIBA 04/2016
1	Histone Deacetylases (Histone Deacetylase)IBA 04/2016

Therapy/Procedure

32	Therapeutics 01/2022 - 12/2003
5	Drug Therapy (Chemotherapy) 01/2020 - 03/2006
3	Transplantation 11/2020 - 03/2016
2	Immunotherapy 10/2018 - 10/2017
1	Precision Medicine 01/2021